Zdravljenje tumorjev ustne votline psov in mačk z metodami elektroporacije

lukam — Fri, 23 Oct 2020 08:47:28 +0000

Electroporation-based treatments for canine and feline oral tumors lukam Fri, 10/23/2020 - 10:52 Small Animal Clinic electroporation electrochemotherapy gene electrotransfer oral tumors dogs cats Research

Electroporation-Based Treatments in Small Animal Veterinary Oral and Maxillofacial Oncology.

Canine and, unfortunatelly less, feline oral tumors are curable if diagnosed early and aggressively treated. In most cases, the best outcome is still achieved with aggressive surgical treatment. If the tumor is large or cannot be completely excised due to its location, surgery can be combined with other treatment types, including electrochemotherapy or gene electrotransfer.

Electroporation is a method in which electrical pulses are used to increase the permeability of the cell membrane. This allows the entry of molecules of interest through the membrane; electrochemotherapy is used to introduce chemotherapeutic drugs inside the tumor cells, whereas gene electrotransfer is used for insertion of plasmid DNA encoding a specific therapeutic gene into cells. Both methods have been proven safe and effective in the treatment of selected cutaneous and subcutaneous tumors in cats and dogs, and are increasingly used in the treatment of oral tumors. They are currently mostly recommended for the treatment of tumors for which clients have declined aggressive surgery and/or radiotherapy, as the treatment results in a good local response, prolongation of survival time and improvement in the quality of life. In the following article, we reviewed all the currently available research describing the use of electroporation-based treatments of canine and feline oral tumors.

At the Small Animal Clinic of the Veterinary Faculty we have been offering electroporation-based treatments for several years as a part of multimodal approach to treatments of tumors. We are committed to the best possible care of your animal while contributing to the development of these treatment methods worldwide. Please, do not hesitate to contact us if your animal was diagnosed with cancer to discuss the possibility of the treatment with electroporation-based methods. In the frame of the new research project “Monitoring of the clinical and immune response to improve the outcome of combined electrochemotherapy and IL-12 gene therapy in dogs with spontaneous peripheral tumours” we are improving these treatment methods further to best serve our patients.

The full article is published in Frontiers in Veterinary Science.

Authors

doc. dr. Ana Nemec¹, Nina Milevoj¹, dr. Urša Lampreht Tratar², prof. dr. Gregor Serša², prof. dr. Maja Čemažar², prof. dr. Nataša Tozon¹

¹ Klinika za male živali, Veterinarska fakulteta
² Oddelek za eksperimentalno onkologijo, Onkološki inštitut Ljubljana

Anestezija in oksidativni stres pri psih z degeneracijo mitralne zaklopke

lukam — Fri, 23 Oct 2020 08:05:03 +0000

Anaesthesia and oxidative stress in dogs with mitral valve degeneration lukam Fri, 10/23/2020 - 10:14 Small Animal Clinic anaesthesia dogs myxomatous mitral valve disease oxidative stress propofol sevoflurane Research

The influence of propofol and sevoflurane anaesthesia on oxidative stress in dogs with myxomatous mitral valve degeneration.

The influence of propofol and sevoflurane anaesthesia on oxidative stress in dogs with myxomatous mitral valve degeneration

The doctoral dissertation of Katerina Tomsič was set out to evaluate whether anaesthesia with propofol, which is believed to have antioxidant properties, causes less oxidative stress in comparison to anaesthesia with propofol and sevoflurane in dogs in which oxidative stress is present due to the myxomatous mitral valve degeneration (MMVD). Anaesthesia with propofol and sevoflurane resulted in increased oxidative stress in dogs with MMVD in comparison to dogs without MMVD, however both anaesthetic protocols can safely be used in dogs with early stage MMVD.

The results of the research were published in two internationally recognized journals:

Authors

Katerina Tomsič, University of Ljubljana, Veterinary Faculty
Alenka Seliškar, University of Ljubljana, Veterinary Faculty
Alenka Nemec Svete, University of Ljubljana, Veterinary Faculty
Ana Nemec, University of Ljubljana, Veterinary Faculty
Aleksandra Domanjko Petrič, University of Ljubljana, Veterinary Faculty
Tatjana Pirman, University of Ljubljana, Biotechnical Faculty
Vida Rezar, University of Ljubljana, Biotechnical Faculty
Tomaž Vovk, University of Ljubljana, Faculty of Pharmacy